Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus.
作者： H Ikegami , Y Kawaguchi , E Yamato , S Kuwata , K Tokunaga
DOI: 10.1210/JCEM.75.5.1358911
关键词:
摘要: DNA sequence analysis of class II HLA from Caucasian and black patients with type 1 (insulin-dependent) diabetes mellitus has suggested that aspartic acid at position 57 (Asp 57) the DQ beta chain provides protection against insulin-dependent (IDDM). In contrast, most Japanese IDDM have Asp 57-positive alleles. To determine reason for differences to localize HLA-linked diabetogenic gene in Japanese, we studied DQA1 DQB1 genes control subjects by polymerase reaction combination restriction fragment length polymorphism analysis. Associations DQA1*0301 DQB1*0303 were observed. DQA1*01 was associated negatively IDDM. The HLA-DR9 haplotype, which is positively DQB1*0303, indicating DR9 haplotype same as caucasians but different blacks. Of loci on hap...
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