Increased Parental Ages and Uniparental Disomy 15: A Paternal Age Effect?

摘要: Parental ages associated with both maternal and paternal uniparental disomy (UPD) of chromosome 15 are highly elevated in comparison to Zurich population-based controls, mean 35.6 38.1, respectively for UPD patients (diagnosed Zurich) 28.0 31.0, controls. The parental also significantly higher than observed trisomies other chromosomes diagnosed Zurich. age cases may be due the fact that two errors, a gain loss 15, necessary. We suggest gamete complementation, zygote formation from gametes one which is nullisomic disomic same chromosome, major mechanism formation, as well secondary trisomic conception, there an association between increased nondisjunction.