Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis.
作者： JM McMahon , S McQuaid , R Reynolds , UF FitzGerald
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摘要: Background:The endoplasmic reticulum (ER) stress pathway may play a role in the pathogenesis multiple sclerosis (MS), and while ER stress-associated molecules have been demonstrated white matter (WM) lesions, these not analysed grey (GM) demyelination.Objective:The objective was to characterise type frequency of GM lesions establish expression profiles stress- hypoxia-associated markers.Methods:Sections from 16 MS cases 12 non-MS controls were stained for (BiP CHOP) D110 antigen.Results:Of analysed, 24% 1 (continuous between WM), 22% 2 (entirely within GM) majority (54%) 3 (extending pia mater). Comparison normal-appearing (NAGM) control tissue showed that NAGM, all had significantly increased levels CHOP compared controls. According morphological dual-labelling criter...
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sci-hub.se 参考文章(37)
Lars Bø, Christian A. Vedeler, Harald I. Nyland, Bruce D. Trapp, Sverre J. Mørk, Subpial demyelination in the cerebral cortex of multiple sclerosis patients. Journal of Neuropathology and Experimental Neurology. ,vol. 62, pp. 723- 732 ,(2003) , 10.1093/JNEN/62.7.723
Chris H. Polman, Petra J. W. Pouwels, Lars Bö, Frederik Barkhof, Jonas A. Castelijns, Jeroen J. G. Geurts, Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. American Journal of Neuroradiology. ,vol. 26, pp. 572- 577 ,(2005)
Hirohito Yamaguchi, Hong-Gang Wang, CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells Journal of Biological Chemistry. ,vol. 279, pp. 45495- 45502 ,(2004) , 10.1074/JBC.M406933200
Wensheng Lin, Brian Popko, Endoplasmic reticulum stress in disorders of myelinating cells. Nature Neuroscience. ,vol. 12, pp. 379- 385 ,(2009) , 10.1038/NN.2273
Marc W. Halterman, Molly Gill, Chris DeJesus, Mitsunori Ogihara, Nina F. Schor, Howard J. Federoff, The Endoplasmic Reticulum Stress Response Factor CHOP-10 Protects against Hypoxia-induced Neuronal Death Journal of Biological Chemistry. ,vol. 285, pp. 21329- 21340 ,(2010) , 10.1074/JBC.M109.095299
Marcin P Mycko, Ruben Papoian, Ursula Boschert, Cedric S Raine, Krzysztof W Selmaj, Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis Clinical Neurology and Neurosurgery. ,vol. 106, pp. 223- 229 ,(2004) , 10.1016/J.CLINEURO.2004.02.019
Fabio Martinon, Xi Chen, Ann-Hwee Lee, Laurie H Glimcher, TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages Nature Immunology. ,vol. 11, pp. 411- 418 ,(2010) , 10.1038/NI.1857
Nj Putkonen, Al Sokka, G Mudo, E Pryazhnikov, Sp Reijonen, L Khiroug, N Belluardo, D Lindholm, L Korhonen, None, Endoplasmic Reticulum Stress Inhibition Protects against Excitotoxic Neuronal Injury in the Rat Brain The Journal of Neuroscience. ,vol. 27, pp. 901- 908 ,(2007) , 10.1523/JNEUROSCI.4289-06.2007
Fabio Martinon, Laurie H Glimcher, Regulation of Innate Immunity by signaling pathways emerging from the endoplasmic reticulum Current Opinion in Immunology. ,vol. 23, pp. 35- 40 ,(2011) , 10.1016/J.COI.2010.10.016
Marc W. Halterman, Christopher De Jesus, David A. Rempe, Nina F. Schor, Howard J. Federoff, Loss of c/EBP-β activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons Molecular and Cellular Neuroscience. ,vol. 38, pp. 125- 137 ,(2008) , 10.1016/J.MCN.2008.01.014