Overexpression of β-Catenin is Responsible for the Development of Portal Hypertension During Liver Cirrhosis
作者： Jian-Jun Hong , Fei-Yan Pan , Yan Qian , Li-Cheng Cheng , Hong-Xia Zhang
DOI: 10.1002/AR.20897
关键词:
摘要: beta-catenin functions as both a structural protein and transcriptional activator. In this study, we examined the expression of in human cirrhotic livers, administered adenoviruses carrying or DeltaTCF4 genes to rats investigate role development liver cirrhosis development. was associated with rat liver. adenovirus capable accelerating progress but progression unaffected by administration adenovirus. mainly located intercellular regions between cells highly concentrated hepatic sinusoid wall, where alpha-smooth muscle actin (SMA) also distributed. The binding alpha-SMA increased Portal vein blood pressure significantly group adenovirus, not that receiving These results suggest high concentrations at membrane wall contribute hyperpiesia patients. molecule, signaling during
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