Ozonation of Propranolol: Transformation, Biodegradability, and Toxicity Assessment

摘要: This work studies the ozonation of pharmaceutical propranolol (PRO) in aqueous solution. Experimental results demonstrated that was an efficient method to remove PRO, achieving its complete abatement after 8 min treatment (ozone dose 0.47  mmol L-1), starting from a PRO initial concentration 0.38  mmol L-1. The total organic carbon (TOC) analysis indicated 1 h 3.54  mmol L-1) able achieve only about 5% removal. solutions has not promoted prompt increase ratio biological oxygen demand chemical demand, thus indicating need for higher ozone doses initiate biodegradability enhancement. acute toxicity increased first minutes reaction with posterior reduction values slightly than raw Some early intermediate structures were proposed, and finally, kinetic constants direct attack on s...