Efficacy of oral, injectable and pour-on formulations of moxidectin against gastrointestinal nematodes in cattle in New Zealand

摘要: The efficacy of moxidectin administered by different routes, against naturally acquired infections gastrointestinal nematode parasites cattle, was compared using faecal egg count reduction tests on 14 commercial farms throughout New Zealand. On each farm, groups 15 calves were sampled for and then treated with ivermectin orally, or either the oral, subcutaneous injection topical (pour-on) route. Samples again collected days after treatment calculated as percentage in-group mean between pre- post-treatment samples. In addition, individual animals, in order to compare variability treatments. four untreated control run five animals from all moxidectin-treated bled over time estimate plasma-moxidectin concentrations. Averaged across tests, significantly greater oral (91.1%) than following (55.5%) pour-on (51.3%). Low efficacies invariably Cooperia oncophora. treatments less variable Moxidectin concentrations plasma highest lowest administration. Plasma levels administration intermediate, being lower post-injection higher post-pour-on. There no evidence transfer through licking. Based these results, along those other studies, it is proposed that macrocyclic lactone anthelmintics results active reaching target worms tract pour-on.