Biochemical and Histopathological Changes in Kidney of Diabetic Rats Treated with Hydroalcoholic Extract of Centaurea cyanus

摘要: Background and purpose: Diabetes mellitus is a common metabolic disease, currently affecting more than 280 million people worldwide. Centaurea cyanus known as cornflower has antioxidant properties used in traditional medicine lowering blood sugar. This study aimed at determining the biochemical histopathological changes serum kidneys of diabetic rats treated with hydroalcoholic extract cyanus. Materials methods: In this study, 60 male Wistar were divided into five groups (n= 12 per group). was induced by alloxan. The for 8 weeks hydro alcoholic C. two concentrations (400 800 mg/kg). Finally, animals anesthetized levels glucose, creatinine urea kidney tissue catalase level measured. slides histopathologically examined. Results: Histopathological examination showed that similar to control group, there no significant histolological features group receiving mg/kg 400 mild tubular changes. Biochemical higher mg/kg. mg/kg, significantly compared group. (P<0.05). Conclusion: Consumption could prevent injuries rats, but further investigations are required before its use treatment patients diabetes.