Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice.

摘要: Melatonin, involved in circadian cycle, provides protective effects on neuronal cells and acts as antidepressant by restoration of corticosterone levels. A mouse model anxiety/depressive-like behavior, induced chronic treatment, has been used to evaluate behavior adult hippocampal neurogenesis mice their possible modulation under melatonin. With this aim, CD1 were subjected 7 wk administration, then behavioral tests novelty-suppressed feeding, open field a forced swim test performed. Cell proliferation dentate gyrus (DG) was investigated 5-bromo-2'-deoxyuridine doublecortin immunohistochemistry techniques, stereological procedure quantify labeled cells. Golgi-impregnated method the changes dendritic spines DG neurons. new therapeutic approach with antidepressant-like substances (3 wk) such melatonin (8 mg/kg) employed possibly modulate neural development hippocampus changes. The depressive-like state caused treatment reversed exogenous administration melatonin; progenitor significantly reduced (cort- 83.7 +/- 20.3 versus cort+ 60.5 18.2; P < 0.05), whereas long-term prevented corticosterone-induced reduction cell 18.2 mel 133.4 26.9; 0.05). Corticosterone-treated exhibited spine density, which ameliorated administration. These findings suggest strong correspondence between neurogenesis, strengthening hypothesis that contributes an antidepressant.