Pathogenesis of HIV-related pulmonary hypertension.
作者： ADRIANO M. PELLICELLI , FABRIZIO PALMIERI , STEFANIA CICALINI , NICOLA PETROSILLO
DOI: 10.1111/J.1749-6632.2001.TB03904.X
关键词:
摘要: Human immunodeficiency virus (HIV)-related pulmonary hypertension (HRPR) is a cardiovascular complication of HIV infection that has been recognized in the last years with increasing frequency. The etiology HRPH unknown. All attempts to isolate on vessels patients failed, and an indirect role for this disease hypothesized. Current theories pathogenesis focus abnormalities endothelial smooth muscle cells vasculature. Endothelial cell injury could be due high production or reduced clearance cytokines these patients. In fact, several studies levels ET-1, IL-1alpha, IL-6 PDGF primary (PPH) have found. gp 120 induce by stimulation monocytes/macrophages. A alpha1-adrenoreceptors also implicated HRPH. Chronic hypoxia observed increased frequency patients, chronic alpha1-receptors vasculature typical pathological changes. However, only small percentage HIV- develop This observation suggests existence idiosyncratic susceptibility development vascular disease. genetic basis, might determined particular major histocompatibility complex alleles.
harvard.edu
elsevier.com
sci-hub.se 参考文章(57)
A Inoue, M Yanagisawa, Y Takuwa, Y Mitsui, M Kobayashi, T Masaki, The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. Journal of Biological Chemistry. ,vol. 264, pp. 14954- 14959 ,(1989) , 10.1016/S0021-9258(18)63795-0
CA Dinarello, Interleukin-1 and interleukin-1 antagonism. Blood. ,vol. 77, pp. 1627- 1652 ,(1991) , 10.1182/BLOOD.V77.8.1627.1627
J E Coligan, H Ehrenreich, F D Goebel, F Sinowatz, L O Arthur, K A Clouse, P R Burd, K A Weih, P Rieckmann, Potent stimulation of monocytic endothelin-1 production by HIV-1 glycoprotein 120. Journal of Immunology. ,vol. 150, pp. 4601- 4609 ,(1993)
Antoine Hadengue, Mohamed Kamal Benhayoun, Didier Lebrec, Jean-Pierre Benhamou, Pulmonary hypertension complicating portal hypertension: prevalence and relation to splanchnic hemodynamics. Gastroenterology. ,vol. 100, pp. 520- 528 ,(1991) , 10.1016/0016-5085(91)90225-A
Peter J. McDonnell, Patryce A. Toye, Grover M. Hutchins, Primary pulmonary hypertension and cirrhosis: are they related? The American review of respiratory disease. ,vol. 127, pp. 437- 441 ,(2015) , 10.1164/ARRD.1983.127.4.437
Philip T Diaz, Thomas L Clanton, Eric R Pacht, None, Emphysema-like Pulmonary Disease Associated with Human Immunodeficiency Virus Infection Annals of Internal Medicine. ,vol. 116, pp. 124- 128 ,(1992) , 10.7326/0003-4819-116-2-124
Patrice Cacoub, Richard Dorent, Geneviève Maistre, Patrick Nataf, Alain Carayon, Jean Charles Piette, Pierre Godeau, Christian Cabrol, Iradj Gandjbakhch, Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome American Journal of Cardiology. ,vol. 71, pp. 448- 450 ,(1993) , 10.1016/0002-9149(93)90452-I
Michael P Bevilacqua, Jordan S Pober, Gerard R Majeau, Walter Fiers, Ramzi S Cotran, Michael A Gimbrone Jr, None, Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 4533- 4537 ,(1986) , 10.1073/PNAS.83.12.4533
Ancel Keys, Albert M. Snell, RESPIRATORY PROPERTIES OF THE ARTERIAL BLOOD IN NORMAL MAN AND IN PATIENTS WITH DISEASE OF THE LIVER: POSITION OF THE OXYGEN DISSOCIATION CURVE Journal of Clinical Investigation. ,vol. 17, pp. 59- 67 ,(1938) , 10.1172/JCI100928
Issei Komuro, Hiroki Kurihara, Takao Sugiyama, Fumimaro Takaku, Yoshio Yazaki, Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Letters. ,vol. 238, pp. 249- 252 ,(1988) , 10.1016/0014-5793(88)80489-7