Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.

摘要: Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that the cost antimicrobial resistance can be by compensatory mutations; however, there is limited evidence evolution has any significant role in success human populations. Here we describe a set mutations RNA polymerase genes rifampicin-resistant M. tuberculosis, etiologic agent tuberculosis (TB). harboring these showed high competitive vitro. Moreover, were associated with vivo, determined examining relative clinical frequency across patient Of note, countries world's highest incidence multidrug-resistant (MDR) TB, more than 30% MDR isolates had this form mutation. Our findings support for global epidemics TB.