Multidisciplinary Canadian consensus recommendations for the management and treatment of hepatocellular carcinoma

摘要: Globally, hepatocellular carcinoma (hcc) is the third most common cause of death from cancer, after lung and stomach cancer. The incidence hcc in Canada increasing expected to continue increase over next decade. Given high mortality rate associated with hcc, steps are required mitigate impact disease. To address this challenging situation, a panel 17 experts, representing gastroenterologists, hepatologists, hepatobiliary surgeons, medical oncologists, pathologists, radiologists across Canada, convened provide framework that, using an evidence-based approach, will assist clinicians optimizing management treatment hcc. recommendations, summarized here, were developed based on rigorous methodology pre-specified process that was overseen by steering committee. Specific topics identified committee delegated group content experts within expert panel, who then systematically reviewed literature topic drafted related recommendations. set recommendations for each assigned level evidence grade according levels out Centre Evidence-based Medicine, Oxford, United Kingdom. Agreement recommendation achieved consensus. Consensus defined as agreement two-thirds majority members panel. Recommendations subject iterative review modification until consensus could be achieved.?