Fetal Brain Subdivisions Defined by R- and E-Cadherin Expressions: Evidence for the Role of Cadherin Activity in Region-Specific, Cell- Cell Adhesion

摘要: Abstract We found that R-cadherin, a Ca 2+ -dependent cell–cell adhesion molecule, is expressed in restricted regions of the mouse fetal brain, as was for E-cadherin previously. R-cadherin delineated subset alar domains within forebrain neuromeres and certain future nuclei, while another distinctive pattern. When cells were collected from various local dissociated, reaggregated under conditions which only cadherins are active cell aggregation, R-cadherin-positive -negative segregated one another. Similar results obtained E-cadherin. Such segregation was, however, suppressed when inactivated either by depletion or with blocking antibodies. These suggest confer region-specific adhesiveness on brain this process may take part segmentation.