Computer-controlled large scale production of high specific activity [11C]RO 15-1788 for PET studies of benzodiazepine receptors

摘要: Abstract Ethyl 8-fluoro-5,6-dihydro-5-[ 11 C]methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine-3-carboxylate ([ C]RO 15-1788) has been prepared automatically with high specific activity for in vivo visualization or quantitative analysis of brain benzodiazepine receptors. The yield, radiochemical purity and the product ready an i.v. injection were 276 ± 76 mCi, 50.8 7.8%,99.3 0.3% 2.9 0.5 Ci/ μ mol, respectively, taking average latest 3 runs. time required was about 25 min. Each sufficient to carry out three successive clinical studies by positron emission tomography (PET). All procedures other than evaporation filtration at final stage carried specially designed equipment connected a central control system radioisotope production.