Vasopressin-sensitive kidney adenylate cyclase. Structural requirements for attachment to the receptor and enzyme activation: studies with vasopressin analogues.
作者： C Roy , T Barth , S Jard
DOI: 10.1016/S0021-9258(19)41605-0
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摘要: Several vasopressin analogues were tested on pig kidney membranes for their ability to activate adenylate cyclase and inhibit the binding of [8-lysine]vasopressin. Both activation hormonal measured same enzyme preparation under identical experimental conditions. A preincubation period in presence hormone allowed process reach equilibrium. Peptide concentrations causing half-maximal (apparent Km) were, order decreasing affinity:2.5 7.0 times 10-10 M [8-lysine] vasopressin, 3.1 4.0 10-9 [8-arginine] 2.0 3.0 [I,6-alpha-deaminocystathionine, 8-ornithine]vasopressin, 10-7 des-9-glycineamide[8-lysine]vasopressin, 0.5 1.0 10-6 M[1,6-alpha-deaminocystathionine, 2-0-tert...
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