Emerging challenges in the extraction, analysis and bioanalysis of cannabidiol and related compounds
作者： Virginia Brighenti , Michele Protti , Lisa Anceschi , Chiara Zanardi , Laura Mercolini
DOI: 10.1016/J.JPBA.2020.113633
关键词:
摘要: Cannabidiol (CBD) is a bioactive terpenophenolic compound isolated from Cannabis sativa L. It known to possess several properties of pharmaceutical interest, such as antioxidant, anti-inflammatory, anti-microbial, neuroprotective and anti-convulsant, being it active multi-target compound. From therapeutic point view, CBD most commonly used for seizure disorder in children. present both medical fiber-type C. plants, but, unlike Δ9-tetrahydrocannabinol (THC), non-psychoactive Non-psychoactive or (also hemp) differs the one, since contains only low levels THC high related cannabinoids. In addition Cannabis, which many different purposes, great expansion market hemp plant material products has been observed recent years, due its usage fields, including food, cosmetics electronic cigarettes liquids (commonly e-liquids). this work focused on advances sample preparation strategies analytical methods chemical analysis compounds material, derived biological samples. Since considered be crucial step development reliable determination natural complex matrices, extraction are discussed. As regards compounds, application separation non-separation discussed detail. The advantages, disadvantages applicability methodologies currently available evaluated. scientific interest portable devices vegetable samples also highlighted.
sci-hub.st 参考文章(180)
Camilla Montesano, Maria Chiara Simeoni, Gabriele Vannutelli, Adolfo Gregori, Luigi Ripani, Manuel Sergi, Dario Compagnone, Roberta Curini, Pressurized liquid extraction for the determination of cannabinoids and metabolites in hair: Detection of cut-off values by high performance liquid chromatography-high resolution tandem mass spectrometry. Journal of Chromatography A. ,vol. 1406, pp. 192- 200 ,(2015) , 10.1016/J.CHROMA.2015.06.021
D. Wianowska, A. L. Dawidowicz, M. Kowalczyk, Transformations of Tetrahydrocannabinol, tetrahydrocannabinolic acid and cannabinol during their extraction from Cannabis sativa L. Journal of Analytical Chemistry. ,vol. 70, pp. 920- 925 ,(2015) , 10.1134/S1061934815080183
Nadine Roth, Bjoern Moosmann, Volker Auwärter, Development and validation of an LC‐MS/MS method for quantification of Δ9‐tetrahydrocannabinolic acid A (THCA‐A), THC, CBN and CBD in hair Journal of Mass Spectrometry. ,vol. 48, pp. 227- 233 ,(2013) , 10.1002/JMS.3152
Ulli Backofen, Frank-Michael Matysik, Craig E Lunte, Determination of cannabinoids in hair using high-pH* non-aqueous electrolytes and electrochemical detection. Some aspects of sensitivity and selectivity. Journal of Chromatography A. ,vol. 942, pp. 259- 269 ,(2002) , 10.1016/S0021-9673(01)01348-6
N Gunasekaran, LE Long, BL Dawson, GH Hansen, DP Richardson, KM Li, JC Arnold, IS McGregor, Reintoxication: the release of fat-stored Δ9-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure British Journal of Pharmacology. ,vol. 158, pp. 1330- 1337 ,(2009) , 10.1111/J.1476-5381.2009.00399.X
Jekaterina Mazina, Anastassija Spiljova, Merike Vaher, Mihkel Kaljurand, Maria Kulp, A rapid capillary electrophoresis method with LED-induced native fluorescence detection for the analysis of cannabinoids in oral fluid Analytical Methods. ,vol. 7, pp. 7741- 7747 ,(2015) , 10.1039/C5AY01595B
Nathalie A. Desrosiers, Karl B. Scheidweiler, Marilyn A. Huestis, Quantification of six cannabinoids and metabolites in oral fluid by liquid chromatography-tandem mass spectrometry Drug Testing and Analysis. ,vol. 7, pp. 684- 694 ,(2015) , 10.1002/DTA.1753
David M. Schwope, Karl B. Scheidweiler, Marilyn A. Huestis, Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry. ,vol. 401, pp. 1273- 1283 ,(2011) , 10.1007/S00216-011-5197-7
Karl B. Scheidweiler, Nathalie A. Desrosiers, Marilyn A. Huestis, Simultaneous quantification of free and glucuronidated cannabinoids in human urine by liquid chromatography tandem mass spectrometry Clinica Chimica Acta. ,vol. 413, pp. 1839- 1847 ,(2012) , 10.1016/J.CCA.2012.06.034
Ivana Novak, Marina Mlakar, Šebojka Komorsky-Lovrić, Voltammetry of immobilized particles of cannabinoids Electroanalysis. ,vol. 25, pp. 2631- 2636 ,(2013) , 10.1002/ELAN.201300410