Chlorhexidine-encapsulated mesoporous silica-modified dentin adhesive.
作者： Huiyi Yan , Shilei Wang , Lin Han , Wenan Peng , Luyao Yi
DOI: 10.1016/J.JDENT.2018.08.012
关键词:
摘要: Abstract Objectives This work aims to explore the feasibility of chlorhexidine-encapsulated mesoporous silica (CHX@pMSN) as a modifier commercial dental adhesive via evaluation physicochemical properties and antibacterial capabilities adhesive–dentin interface. Methods Therapeutic adhesives were developed in present study by incorporating CHX@pMSN into at four mass fractions (0, 1, 5 10 wt.%). The capability on Streptococcus mutans (S. mutans) biofilm, conversion degree, morphology, microtensile bond strength (MTBS) nanoleakage expression evaluated comprehensively. Results MTT CLSM showed that CHX@pMSN-doped inhibits S. biofilm growth, while CHX is released from modified continuously. incorporation did not affect immediate concentration 1% 5% (P > 0.05). Moreover, these bonds mainly preserved group after one month collagenase ageing. Meanwhile, groups exhibited similar distribution compared with control. Conclusion CHX@pMSN-modified achieved balance amongst unaffected bonding strength, well-preserved against ageing effective inhibition growth. Clinical significance dentin can potentially extend service life restoration clinic.
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