The genetics of drug resistance in malaria parasites.

摘要: Abstract The available experimental data on the genetics of drug resistance in malaria parasites are reviewed. Seven possible mechanisms for origin considered, and it is pointed out that spontaneous gene mutation probably most important. Experiments production pyrimethamine-resistant chloroquine-resistant strains rodent Plasmodium species, inheritance such resistance, Relevant biochemical also considered relation to resistance. Studies competition between drug-sensitive drug-resistant mixed populations plasmodia described. The implications these findings P. falciparum discussed.