The effect of chronic administration of hydroxyzine on hydroxyzine pharmacokinetics in dogs.

摘要: Abstract Subsensitivity to H 1 -receptor antagonists has been attributed autoinduction of enzyme systems and increased clearance rates during chronic drug administration. We studied the changes in serum half-life values dogs who were administered hydroxyzine, 0.7 mg/kg, intramuscularly, daily, for 150 days. Pharmacokinetic studies performed on first day administration, days 30, 60, 90, 120, 150. The mean value 120 was significantly longer ( p antagonist is not due systems, more rapid drug, lower concentrations te tissue.