Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model.
作者： Martha H. Stipanuk , Halina Jurkowska , Julie Niewiadomski , Kevin M. Mazor , Heather B. Roman
DOI: 10.1007/978-94-024-1079-2_38
关键词:
摘要: The cysteine dioxygenase (Cdo1)-null mouse is unable to synthesize hypotaurine and taurine by the cysteine/cysteine sulfinate pathway has very low levels in all tissues. lack of associated with a conjugation bile acids, dramatic increase total unconjugated hepatic acid pools, an betaine other molecules that serve as organic osmolytes. We used Cdo1-mouse model determine effects deficiency on expression proteins involved sulfur amino metabolism. identified sulfinic decarboxylase (Csad), betaine:homocysteine methytransferase (Bhmt), cholesterol 7α-hydroxylase (Cyp7a1), cytochrome P450 3A11 (Cyp3a11) genes whose strongly regulated response depletion Cdo1-null mouse. Dietary supplementation mice restored these four their respective mRNAs wild-type levels, whereas dietary had no effect abundance or mice.
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