Medicinal attributes of Solanum xanthocarpum fruit consumed by several tribal communities as food: an in vitro antioxidant, anticancer and anti HIV perspective
作者： Shashank Kumar , Abhay K Pandey
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摘要: Solanum xanthocarpum (Solanaceae) has been used for treatment of many infectious and degenerative diseases in traditional medicine. Present study reports the medicinal efficacy S. fruit as antioxidant, anticancer anti HIV agents. Extracts were prepared using Soxhlet apparatus partially characterized by thin layer chromatography (TLC). Total flavonoid content was determined spectrophotometrically. Reducing power, DPPH radical scavenging activity lipid peroxidation inhibition assays measurement antioxidant potential. Cytotoxic (SRB assay) anti-HIV RT (RT assay kit, Roche) activities ELISA. TLC revealed diversity phytoconstituents various sequential extracts fruit. contents ranged between 10.22–162.49 μg quercetin equivalent/mg. Spectroscopic scanning water soluble phenolics showed maximum absorbance at 250 280 nm. Polar displayed potent (>80%). Several sub-fractions (spots) separated on plates also exhibited powerful activity. Considerable reducing power observed extracts. Hexane fraction provided 55% lipoprotection rat kidney homogenate. Non-polar appreciable cytotoxic (70-91%) against leukemia (THP-1) lung cancer (HOP-62) cell lines. Lower inhibitory Reverse Transcriptase enzyme. The demonstrated considerable
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B Sharma, A Bhargava, S Kumar, A K Pandey, A Mishra, Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants. Cellular and Molecular Biology. ,vol. 57, pp. 16- 25 ,(2011)
P. Revathi, T. Parimelazhagan, Traditional Knowledge on Medicinal Plants Used by the Irula Tribe of Hasanur Hills, Erode District, Tamil Nadu, India Ethnobotanical Leaflets. ,vol. 2010, pp. 4- ,(2010)
A Mishra, A K Pandey, A K Mishra, Antifungal and antioxidative potential of oil and extracts derived from leaves of Indian spice plant Cinnamomum tamala. Cellular and Molecular Biology. ,vol. 58, pp. 142- 147 ,(2012)
X. Ye, R.L. Krohn, W. Liu, S.S. Joshi, C.A. Kuszynski, T.R. McGinn, M. Bagchi, H.G. Preuss, S.J. Stohs, D. Bagchi, The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Molecular and Cellular Biochemistry. ,vol. 196, pp. 99- 108 ,(1999) , 10.1023/A:1006926414683
S Kumar, AK Pandey, None, Antioxidant, Lipo-Protective and Antibacterial Activities of Phytoconstituents Present in Solanum Xanthocarpum Root International Review of Biophysical Chemistry. ,vol. 3, pp. 42- 47 ,(2012) , 10.15866/IREBIC.V3I3.1557
Catherine Rice-Evans, Lester Packer, Flavonoids in health and disease Marcel Dekker. ,(2003) , 10.1201/9780367803681
Chuong Pham-Huy, Hua He, Lien Ai Pham-Huy, Free Radicals, Antioxidants in Disease and Health International journal of biomedical science : IJBS. ,vol. 4, pp. 89- 96 ,(2008)
Kristiina Wähälä, Lothar Schweigerer, Theodore Fotsis, Herman Adlercreutz, Michael S. Pepper, Roberto Montesano, Erkan Aktas, Sirpa Rasku, Stephen Breit, Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Research. ,vol. 57, pp. 2916- 2921 ,(1997)
Amita Chandra, Amita Mishra, Ajay Kumar Mishra, Shashank Kumar, Abhay K. Pandey, Therapeutic potential of C.Zeylanicum extracts: an antifungal and antioxidant perspective ,(2010)
Ajay K Mishra, Amita Mishra, HK Kehri, Bechan Sharma, Abhay K Pandey, Inhibitory activity of Indian spice plant Cinnamomum zeylanicum extracts against Alternaria solani and Curvularia lunata , the pathogenic dematiaceous moulds Annals of Clinical Microbiology and Antimicrobials. ,vol. 8, pp. 9- 9 ,(2009) , 10.1186/1476-0711-8-9