Requirement of Activation of JNK and p38 for Environmental Stress-Induced Erythroid Differentiation and Apoptosis and of Inhibition of ERK for Apoptosis
作者： Yuka Nagata , Kazuo Todokoro
DOI: 10.1182/BLOOD.V94.3.853.415A12_853_863
关键词:
摘要: C-Jun amino terminal kinase/stress-activated protein kinases (JNK/SAPK) and p38 subgroups of mitogen-activated have been suggested to play a critical role in apoptosis, cell growth, and/or differentiation. We found that short exposure SKT6 cells, which respond erythropoietin (Epo) induce erythroid differentiation, osmotic or heat shock induced transient activation JNK/SAPK inactivation ERK resulted differentiation without Epo, whereas long the cells these stresses prolonged activation/inactivation same caused apoptosis. Inhibition inhibition stress-induced had no effect on but stimulated Activation for time although its suppressed These results indicate cellular stresses, inducing p38, lead rather than Furthermore, is required both duration their may determine fate, In contrast, apoptosis not
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