The Potential Application and Risks Associated With the Use of Predatory Bacteria as a Biocontrol Agent Against Wound Infections

摘要: Abstract : Disease-causing microorganisms that have become resistant to drug therapy are an increasing cause of burn, wound, blast and bone infections, with many traditional antimicrobial agents becoming ineffective. Our main hypothesis is predatory prokaryotes could serve as a novel therapeutic agent control wound-related bacterial infections. In previous study, we confirmed bacteria Bdellovibrio bacteriovorus Micavibrio aeruginosavorus able prey on wide range pathogens including isolated from Wounded Warriors. The aim this proposal address key questions regarding the safety efficacy investigating predator interactions resistance. Using enrichment culturing techniques verified no genetically stable predation phenotype developed in K. pneumoniae A. baumannii host cells following sequential by B. bacteriovorus. Furthermore, M. also did not yield data predators do breach their specificity attack previously bacteria. Additional experiments produce which exhibit enhance selected but were acclimated at elevated temperatures.