A single amino acid change converts an inhibitory transcription factor into an activator.
作者： Sally J. Dawson , Peter J. Morris , David S. Latchman
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摘要: The closely related POU family transcription factors Brn-3a and Brn-3b differ in their functional activity with activating several target promoters, which are repressed by Brn-3b. also prevents promoter activation Brn-3a. Here we have altered a single isoleucine residue the homeodomain of to valine found at equivalent position This change not only abolishes ability repress basal Brn-3a-stimulated but converts it an activator similar potency Hence amino acid difference determines between repressor Brn-3 family.
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