IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART.
作者： María Guzmán-Fulgencio , Juan Berenguer , María Angeles Jiménez-Sousa , Dariela Micheloud , Mónica García-Álvarez
DOI: 10.1111/ECI.12539
关键词:
摘要: Background The IL7RA polymorphisms have recently been associated with CD4+ T-cell decline in untreated HIV-infected subjects and recovery patients on combination antiretroviral therapy (cART). The aim of this study was to evaluate whether are long-term cART. Study design We performed a retrospective 151 naive cART severe immunodeficiency (CD4+ counts ≤200 cells/mm3). polymorphisms' genotyping using Sequenom's MassARRAY platform. outcome variable the time achieve first value count ≥500 cells/mm3 during follow-up. Results Two different trends were found Kaplan–Meier analysis. During 48 months, 60 (39·7%) reached values cells/mm3, no differences observed between genotypes. After 48 months follow-up, 27 (17·8%) pattern depending genotype. Patients rs10491434 TT genotype rs6897932 more likely achieving than CT/CC (adjusted hazard ratio (aHR) = 3·59; P = 0·005) CC/CT (aHR = 11·7; P < 0·001). Conclusions The seem be who started immunodeficiency, second phase after cART.
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