Oxidative metabolism: glucose versus ketones.

摘要: The coupling of upstream oxidative processes (glycolysis, beta-oxidation, CAC turnover) to mitochondrial phosphorylation (OXPHOS) under the driving conditions energy demand by cell results in liberation free as ATP. Perturbations glycolytic or OXPHOS can result pathology death. To better understand whole body expenditure during chronic ketosis, we used a diet-induced rat model ketosis determine if high-fat-carbohydrate-restricted “ketogenic” diet changes total (TEE). Consistent with previous reports increased mice, hypothesized that rats fed ketogenic for 3 weeks would resting due alterations metabolism associated “switch” substrate from glucose ketone bodies. rationale is bodies are more efficient fuel than glucose. Indirect calorimetric analysis revealed moderate increase VO2 and decreased VCO2 heat ketosis. These suggest induces uncoupling state less efficiency compared oxidation.