Facile, One‐Pot, and Gram‐Scale Synthesis of 3,4,5‐Triiodoanisole through a C–H Iodination/ipso‐Iododecarboxylation Strategy: Potential Application towards 3,4,5‐Trisubstituted Anisoles
作者： Raed M. Al-Zoubi , Hussein Al-Mughaid , Mariam A. Al-Zoubi , Khaled T. Jaradat , Robert McDonald
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摘要: A facile, efficient, and gram-scale method for the conversion of para-anisic acid into 3,4,5-triiodoanisole through a one-pot C–H iodination/ipso-iododecarboxylation reaction was investigated. Commercially available benzoic used, which allowed to be performed on multigram scale in good yield. This report discloses practical synthesis hitherto unknown that is catalytic, scalable, easy work up purify. Potential application target compound as precursor novel site-selective metal–iodine exchange Suzuki–Miyaura cross-coupling reactions were also explored. 3,4,5-Trisubstituted anisole derivatives provided highly regioselective fashion; these compounds are useful building blocks indeed hard prepare by any other means.
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