Bioavailability of long chain omega-3 polyunsaturated fatty acids from phospholipid-rich herring roe oil in men and women with mildly elevated triacylglycerols

摘要: This randomized, single-blind, crossover trial assessed the bioavailability of eicosapentaenoic acid (EPA), docosahexaenoic (DHA), and docosapentaenoic acid (DPA) from two different sources, each examined over a 12h period following consumption single serving after 2-weeks daily supplementation. Thirty-two adults with fasting triacylglycerol (TAG) concentrations between 100 399mg/dL were randomly assigned, stratification by sex age, to receive 12 capsules/day containing either phospholipid (PL)-rich herring roe oil (Romega® 30, 628mg/day EPA; 1810mg/day DHA; 137mg/day DPA) or TAG-rich fish (575mg/day 1843mg/day 259mg/day for 2-week separated 4 week washout. The net incremental area under curve 0 EPA, DHA, EPA+DHA in plasma phosphatidylcholine (PC) significantly higher (p<0.01 all) Romega 30 supplementation compared oil. Similar results observed when data condition normalized EPA DHA intakes (p<0.001 all). After period, PC EPA+ was elevated ~2.8 3.0-fold relative baseline both conditions (p<0.0001 each), but there no significant difference change (p=0.422) (baseline=62.2±3.8µg/mL vs. end study=172.9±11.7µg/mL) (baseline=62.0±3.4µg/mL study=185.4±11.2µg/mL) conditions. individual LC n-3 PUFA 2 weeks These demonstrate that PL-rich is well-tolerated bioavailable source PUFA.