Formation of mammalian erythrocytes: chromatin condensation and enucleation

摘要: In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during final stages of red biogenesis. Enucleation, process by which is extruded budding off from erythroblast, unique to mammals. Enucleation has critical physiological evolutionary significance in that it allows an elevation hemoglobin levels blood also gives cells their flexible biconcave shape. Recent experiments reveal enucleation involves multiple molecular cellular pathways include histone deacetylation, actin polymerization, cytokinesis, cell–matrix interactions, specific microRNAs vesicle trafficking; many evolutionarily conserved proteins genes have been recruited participate this uniquely mammalian process. review, we discuss recent advances erythroblast chromatin condensation enucleation, conclude with our perspectives on future studies.