Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia

摘要: Six women developed chronic long-term arthropathy after postpartum immunization against rubella. All individuals acute polyarticular arthritis within 12 days to three weeks postimmunization and have had continuing or recurrent arthralgia for two seven years vaccination. Acute neurological manifestations, consisting of carpal tunnel syndrome multiple paresthesiae, postvaccination in women. Two active episodes blurred vision, painful limb syndromes together with joint symptoms. Chronic rubella viremia has been detected peripheral blood mononuclear cell (MNC) populations five the six up In addition virus was isolated from breast milk MNCs one individual at nine months four breast-fed infants studied 12-18 age. Immune responses sequential intervals vaccination correlated development rheumatologic manifestations.