作者: N.J White , P.L Olliaro
DOI: 10.1016/0169-4758(96)10055-7
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摘要: Abstract Among the several ‘tropical' diseases that affect humans, malarin poses special control problems due to increasing population at risk from disease, difficulties in eradicating mosquito vector tropics and emergence spread of parasite resistance commonly used antimalarial drugs. There is both clinical experience experimental evidence that, however effective when first introduced, lifespan drugs inevitably curtailed by resistant parasites. Resistance most important factor determining useful In this review, Nick White Piero Olliaro discuss rationale for combination chemotherapy.