Differential diagnosis of AKI in clinical practice by functional and damage biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference.

摘要: Acute kidney injury (AKI) is a common but complex clinical syndrome with multiple etiologies. These etiologies target different sites and pathways within the kidney. Novel biomarkers of 'kidney damage' (which can be tubular or glomerular) used to diagnose AKI, even in absence an increase serum creatinine oliguria. damage combined function facilitate classification AKI. A comprehensive review literature was performed using published methodology Dialysis Quality Initiative (ADQI) working group establish consensus statements regarding use differential diagnosis We recommend that pathophysiological terms 'functional change' preference anatomical pre-renal, renal post-renal further both non-renal establishing specific cause AKI as soon possible after diagnosis. The presence underlying CKD sepsis poses additional challenges diagnosis, since these conditions alter baseline biomarker excretion performance. validated context which they are used. Within context, combinations may, future, allow differentiation site, mechanism phase injury.