Informed consent for whole-genome sequencing studies in the clinical setting. Proposed recommendations on essential content and process

摘要: The development of new massive sequencing techniques has now made it possible to significantly reduce the time and costs whole-genome (WGS). Although WGS will soon become a routine testing tool, ethical issues have surfaced. In light these concerns, systematic review papers published by expert authors on IC or specific related for analysis in clinical setting been conducted using Pubmed, Embase Cochrane Library databases. Additionally, search was international guidelines genetic studies scientific societies boards. Based documents, minimum set information be provided patients form determined. Fourteen seven documents from database societies, respectively, were selected. A very high level consistency between them found regarding recommended content. Pre-test counselling general common all tests should included diagnostic purposes, but additional addressing are proposed, such as plan ethical, clinically oriented return incidental findings. Moreover, storage future use also agreed upon with patient advance. Recommendations concerning both elements process obtaining well how handle results obtained proposed.