Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis.
作者： Y. Shimizu , K. Yokoyama , T. Misu , T. Takahashi , K. Fujihara
DOI: 10.1007/S00415-007-0730-5
关键词:
摘要: Sirs: Relapsing neuromyelitis optica (RNMO) is characterised by recurrent longitudinally extensive myelitis (RLEM) and severe optic neuritis [5, 7, 10, 14]. The effects of disease-modifying therapies, including interferon beta (IFNβ), have not been fully established in RNMO or RLEM [15]. immunoglobulin G (NMO-IgG) auto-antibody (Ab) a marker for NMO [3], which binds to the aquaporin 4 (AQP4) water channel protein [2]. AntiAQP4 antibody titres may implications diagnosing [13]. We report two cases with anti-AQP4 Ab, (tumefactive) brain lesions developed within 2 months after initiation IFNβ-1b.
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