High genetic diversity in Schistosoma mansoni in the Senegal River Basin: a population genetic analysis 20 years after the epidemic outbreak

摘要: About twenty years ago, two dams were constructed in the Senegal River Basin (SRB) order to improve agricultural conditions Northern Senegal. The subsequent ecological changes stimulated growth and spreading of Bulinus Biomphalaria snail species, intermediate hosts Schistosoma haematobium S. mansoni, respectively. This resulted a major outbreak intestinal schistosomiasis. A recent study highlighted an increase urinary schistosomiasis while infection intensity is decreasing for mansoni (Polman K, pers. comm.). unique system where origin epidemic exactly known its evolution carefully monitored, providing opportunity molecular pathogens relative short time frame. Demographic parameters such as effective population size reflects adaptive potential parasite, i.e. how parasite can cope with selection pressure host or environment, gene flow estimates illustrate transmission dynamics between populations localities. Here we report on genetic structure mansoni. In March 2006 2007, urine stool samples collected along lower middle valley SRB. Eggs have been isolated hatched. Individual miracidia Whatman FTAR indicator cards genotyped 9 microsatellite loci (a single multiplex). has also sequenced ITS1 rDNA partial cox1 mtDNA. thorough analysis revealed high diversity within populations, but low differentiation suggesting extensive migration villages.