Factors influencing life satisfaction in acute myeloid leukemia survivors following allogeneic stem cell transplantation: a cross-sectional study.

作者: Susanne Amler , Maria Sauerland , Christian Deiters , Thomas Büchner , Andrea Schumacher

DOI: 10.1186/S12955-015-0222-8

关键词:

摘要: Allogeneic stem cell transplantation (alloSCT) is the preferred option of postremission therapy for high-risk patients suffering from acute myeloid leukemia (AML). Therefore, monitoring life satisfaction (LS) long-term survivors following alloSCT becoming increasingly important oncologists. The aim study was to evaluate individual survivor priority various general and health-related domains their with these domains. Furthermore, we investigated impact LS on resilience, anxiety, depression quality in AML alloSCT. Forty-one (median age at time assessment = 49.0 years) who had undergone since transplantation = 3.1 years) were enrolled study. Psychosocial parameters assessed using instruments: FLZM (Questions Life Satisfaction), EORTC QLQ-C30, HADS (Hospital Anxiety Depression Scale) RS-25 (Resilience Scale-25 items). Correlation analyses computed reveal associations between different questionnaires. Independence help or care, well-regulated living conditions financial security contributed positively LS, whereas being off work due health-reasons dissatisfaction physical aspects negatively associated subjective feelings overall satisfaction. Moreover, a high strongly correlated (Spearman’s rho LS: 0.643 0.726, both p < 0.001). A degree resilience also better (general 0.700, 0.675, Symptoms anxiety an impaired (anxiety: −0.674, depression: −0.698, Our results indicate that should be considered key contributor survivors’ well-being Thus, identifying protective psychological factors relieve stressors importance order support special needs.

参考文章(52)
Gail M. Wagnild, Heather M. Young, Development and psychometric evaluation of the Resilience Scale Journal of Nursing Measurement. ,vol. 1, pp. 165- 178 ,(1993)
Sandra Broers, Ad A. Kaptein, Saskia Le Cessie, W. Fibbe, Michiel W. Hengeveld, Psychological functioning and quality of life following bone marrow transplantation: a 3-year follow-up study. Journal of Psychosomatic Research. ,vol. 48, pp. 11- 21 ,(2000) , 10.1016/S0022-3999(99)00059-8
Torsten Haferlach, Axel Heyll, Christa Fonatsch, Maria-Cristina Sauerland, Achim Heinecke, Wolfgang Hiddemann, Bernhard Wörmann, Dieter Hossfeld, Helmut Löffler, Detlef Haase, Claudia Schoch, Georg Maschmeyer, Wolf-Dieter Ludwig, Eva Lengfelder, Winfried Gassmann, Carlo Aul, Thomas Büchner, Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group. Blood. ,vol. 93, pp. 4116- 4124 ,(1999) , 10.1182/BLOOD.V93.12.4116
Jochen Hardt, Dragana Filipas, Rudolph Hohenfellner, Ulrich T. Egle, Quality of life in patients with bladder carcinoma after cystectomy: First results of a prospective study Quality of Life Research. ,vol. 9, pp. 1- 12 ,(2000) , 10.1023/A:1008927809013
Frank Wilcoxon, Individual Comparisons by Ranking Methods Springer Series in Statistics. ,vol. 1, pp. 196- 202 ,(1992) , 10.1007/978-1-4612-4380-9_16
Jada G. Hamilton, Lisa M. Wu, Jane E. Austin, Heiddis Valdimarsdottir, Katie Basmajian, AnnaMarie Vu, Scott D. Rowley, Luis Isola, William H. Redd, Christine Rini, Economic survivorship stress is associated with poor health-related quality of life among distressed survivors of hematopoietic stem cell transplantation Psycho-Oncology. ,vol. 22, pp. 911- 921 ,(2013) , 10.1002/PON.3091
Kris Ann P. Schultz, Lu Chen, Zhengjia Chen, Toana Kawashima, Kevin C. Oeffinger, William G. Woods, H. Stacy Nicholson, Joseph P. Neglia, Health Conditions and Quality of Life in Survivors of Childhood Acute Myeloid Leukemia Comparing Post Remission Chemotherapy to BMT: A Report from the Children's Oncology Group Pediatric Blood & Cancer. ,vol. 61, pp. 729- 736 ,(2014) , 10.1002/PBC.24881
Donna B. Greenberg, Alice B. Kornblith, James E. Herndon, Enid Zuckerman, Charles A. Schiffer, Raymond B. Weiss, Robert J. Mayer, Silkaly M. Wolchok, Jimmie C. Holland, Quality of life for adult leukemia survivors treated on clinical trials of Cancer and Leukemia Group B during the period 1971-1988: predictors for later psychologic distress. Cancer. ,vol. 80, pp. 1936- 1944 ,(1997) , 10.1002/(SICI)1097-0142(19971115)80:10<1936::AID-CNCR10>3.0.CO;2-Z
H. B. Mann, D. R. Whitney, On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other Annals of Mathematical Statistics. ,vol. 18, pp. 50- 60 ,(1947) , 10.1214/AOMS/1177730491