Prognostic Importance of Pathophysiologic Markers in Patients With Heart Failure and Preserved Ejection Fraction
作者： Andrew J. Sauer , Jonathan D. Rich , Benjamin H. Freed , Sanjiv J. Shah , Michael A. Burke
DOI: 10.1161/CIRCHEARTFAILURE.113.000854
关键词:
摘要: Background—Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome associated multiple pathophysiologic abnormalities, including left ventricular (LV) diastolic dysfunction, longitudinal LV systolic abnormal ventricular-arterial coupling, pulmonary hypertension, and right (RV) remodeling/dysfunction. However, the relative prognostic significance of each these abnormalities in HFpEF unknown. Methods Results—We prospectively studied 419 patients using echocardiography sphygmomanometry to assess markers. Cox proportional hazards analyses were used determine associations between markers outcomes. Mean age was 65±12 years; 62% women; 39% black; comorbidities common; study participants met published criteria for HFpEF. RV frequent: 28% had tricuspid annular plane excursion, 15% reduced fractional area ...
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