Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity.

摘要: The antigen receptor on T cells (TCR) has been predicted to have a structure similar membrane-anchored form of an immunoglobulin F(ab) fragment. Virtually all the conserved amino acids that are important for inter- and intramolecular interactions in VH-VL pair also TCR V alpha beta chains. A molecular model constructed by homology we used information from this, as well earlier structural predictions others, study basis specificity. Specifically, regions cloned antigen-specific cell were stitched into corresponding framework second TCR. Results indicate substitution acid sequences complementarity determining (CDRs) can convey specificity major histocompatibility complex molecules. These data consistent with role, but not exclusive CDR3 peptide recognition.