Dose-dependent transitions in mechanisms of toxicity: case studies

作者: William Slikker Jr , Melvin E Andersen , Matthew S Bogdanffy , James S Bus , Steven D Cohen

DOI: 10.1016/J.TAAP.2004.06.027

关键词:

摘要: Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full dose–response curve. It is …

参考文章(540)
F. Peter Guengerich, Dong Hyun Kim, Masahiko Iwasaki, Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects Chemical Research in Toxicology. ,vol. 4, pp. 168- 179 ,(1991) , 10.1021/TX00020A008
Quanxin Meng, Rogene F Henderson, Lingyan Long, Lee Blair, Dale M Walker, Patricia B Upton, James A Swenberg, Vernon E Walker, Mutagenicity at the Hprt locus in T cells of female mice following inhalation exposures to low levels of 1,3-butadiene Chemico-Biological Interactions. ,vol. 135-136, pp. 343- 361 ,(2001) , 10.1016/S0009-2797(01)00222-8
T M Monticello, K T Morgan, L Uraih, Nonneoplastic nasal lesions in rats and mice. Environmental Health Perspectives. ,vol. 85, pp. 249- 274 ,(1990) , 10.1289/EHP.85-1568333
A. Blair, P. Hartge, P. A. Stewart, M. McAdams, J. Lubin, Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up. Occupational and Environmental Medicine. ,vol. 55, pp. 161- 171 ,(1998) , 10.1136/OEM.55.3.161
H�kan Eriksson, Katarina M�giste, Lars-Olof Plantin, Frode Fonnum, Karl-G�ran Hedstr�m, Elvar Theodorsson-Norheim, Krister Kristensson, Erik St�lberg, Edith Heilbronn, Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation Archives of Toxicology. ,vol. 61, pp. 46- 52 ,(1987) , 10.1007/BF00324547
Philip C. Burcham, Andrew W. Harman, Effect of acetaminophen hepatotoxicity on hepatic mitochondrial and microsomal calcium contents in mice Toxicology Letters. ,vol. 44, pp. 91- 99 ,(1988) , 10.1016/0378-4274(88)90134-8
Michael R. Halvorson, Jimmie K. Noffsinger, Charles M. Peterson, Studies of whole blood-associated acetaldehyde levels in teetotalers Alcohol. ,vol. 10, pp. 409- 413 ,(1993) , 10.1016/0741-8329(93)90029-N