Comparison of plasma pharmacokinetics and bioequivalence of ceftiofur sodium in cattle after a single intramuscular or subcutaneous injection

摘要: Ceftiofur sodium, a broad-spectrum cephalosporin, is active against gram-positive and gram-negative pathogens of veterinary importance. This study was designed to compare the bioequivalence sodium salt in cattle after single intramuscular (i.m.) or subcutaneous dose (s.c.) 2.2 mg ceftiofur equivalents/kg body weight. The criteria used evaluate were (1) area under curve from time injection limit quantitation (LOQ) assay (AUC0-LOQ), (2) concentrations remained above 0.2 microg/mL (t>0.2). Twelve crossbred beef enrolled three-period, two-treatment crossover trial, with minimum 2-week washout period between doses equivalents/kg. Blood samples collected serially for up 72 h post-injection. Plasma then analyzed using validated that measures ceftiofur, all desfuroylceftiofur-related metabolites, by high-performance liquid chromatography (HPLC) as stable derivative, desfuroylceftiofur acetamide. A maximum plasma concentration (Cmax) 13.9+/-3.55 observed 0. 67-2.0 i.m. administration, whereas Cmax 13.6+/-3.85 0.67-3.0 s.c. administration. AUC0-LOQ 108+/-35.0 microg. h/mL dosing, compared 105+/-29.8 dosing. pre-established criterion equivalence routes administration satisfied. t>0.2 49.2+/-8.55 47.0+/-9.40 equivalents (CE)/kg suggest similar therapeutic efficacy systemic safety two