Intronic U50 small‐nucleolar‐RNA (snoRNA) host gene of no protein‐coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B‐cell lymphoma

摘要: Background In eukaryotic cells, nucleolar processing of preribosomal RNAs (prerRNAs) is assisted by a large number small (snoRNAs) that function in the 2′-O-methylation or pseudouridylation rRNAs. Most snoRNAs so far characterized are encoded and processed from introns premRNAs. Results We found novel intronic snoRNA gene, named U50HG, located on chromosome 6q15, at breakpoint chromosomal translocation t(3;6)(q27;q15). The U50HG gene composed six exons, whose spliced transcripts have little potential for coding protein, its produce both U50 U50-like (U50′) localized nucleoli. It possesses an oligopyrimidine tract characteristic 5′-terminal (5′TOP) class genes which been shown to be coordinately regulated response cell growth. Conclusions U50HG member nonprotein-coding multiple host family, as well 5′TOP family similar UHG (U22 gene), U17HG (U17 U19HG (U19 gene) gas5 (growth arrest-specific transcript 5 gene). find t(3;6)(q27;q15) involved human B-cell lymphoma.