Wnt signaling pathway in cardiac fibrosis: New insights and directions
作者： Hui Tao , Jing-Jing Yang , Kai-Hu Shi , Jun Li
DOI: 10.1016/J.METABOL.2015.10.013
关键词:
摘要: Abstract Objective Wnt signaling pathway significantly participates in cardiac fibrosis and CFs activation. Therefore, we reviewed current evidence on the new perspectives biological association between fibrosis. Design Methods A PubMed database search was performed for studies of Results Numerous have shown that pathogenesis. The aim this review is to describe present knowledge about participating activation, look ahead research. Moreover, will discuss different insights interact with pathway-regulated proteins are glycoproteins bind Fz receptors cell surface, which lead several important functions, such as differentiation proliferation. There signals among characterized pathways fibrosis, including Wnt/β-catenin signaling. In review, insight into pathogenesis discussed, special emphasis Wnt/β-catenin. Conclusion It seems reasonable suggest potential targets it can be developed a therapeutic target
sci-hub.se 参考文章(115)
Michael P. Flaherty, Timothy J. Kamerzell, Buddhadeb Dawn, Wnt Signaling and Cardiac Differentiation Progress in Molecular Biology and Translational Science. ,vol. 111, pp. 153- 174 ,(2012) , 10.1016/B978-0-12-398459-3.00007-1
Rachel K. Miller, Ji Yeon Hong, William A. Muñoz, Pierre D. McCrea, Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling. Progress in Molecular Biology and Translational Science. ,vol. 116, pp. 387- 407 ,(2013) , 10.1016/B978-0-12-394311-8.00017-0
Lei Dong, Hui Chen, Yu Peng Wang, Yong Quan Wu, Ping Wang, Hong Wei Li, Min Li, Relaxin inhibit cardiac fibrosis induced by phorbol 12-myristate 13-acetate. Biomedical and Environmental Sciences. ,vol. 27, pp. 138- 141 ,(2014) , 10.3967/BES2014.030
Kenneth Offit, Heather Pierce, Tomas Kirchhoff, Prema Kolachana, Beth Rapaport, Peter Gregersen, Steven Johnson, Orit Yossepowitch, Helen Huang, Jaya Satagopan, Mark Robson, Lauren Scheuer, Khedoudja Nafa, Nathan Ellis, Frequency of CHEK2*1100delC in New York breast cancer cases and controls BMC Medical Genetics. ,vol. 4, pp. 1- 4 ,(2003) , 10.1186/1471-2350-4-1
J P Dijksterhuis, J Petersen, G Schulte, WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 British Journal of Pharmacology. ,vol. 171, pp. 1195- 1209 ,(2014) , 10.1111/BPH.12364
Ming Chang Hu, Makoto Kuro-o, Orson W. Moe, Klotho and Chronic Kidney Disease Contributions To Nephrology. ,vol. 180, pp. 47- 63 ,(2013) , 10.1159/000346778
Elizabeth A Musgrove, Wnt signalling via the epidermal growth factor receptor: a role in breast cancer? Breast Cancer Research. ,vol. 6, pp. 65- 68 ,(2003) , 10.1186/BCR737
Yi Shuai, Jun Guo, Yansheng Dong, Weijian Zhong, Ping Xiao, Tong Zhou, Lishi Zhang, Shuangqing Peng, Global gene expression profiles of MT knockout and wild-type mice in the condition of doxorubicin-induced cardiomyopathy Toxicology Letters. ,vol. 200, pp. 77- 87 ,(2011) , 10.1016/J.TOXLET.2010.10.017
Maryline Abrial, Claire Crola Da Silva, Bruno Pillot, Lionel Augeul, Fabrice Ivanes, Geoffrey Teixeira, Régine Cartier, Denis Angoulvant, Michel Ovize, René Ferrera, Cardiac fibroblasts protect cardiomyocytes against lethal ischemia–reperfusion injury Journal of Molecular and Cellular Cardiology. ,vol. 68, pp. 56- 65 ,(2014) , 10.1016/J.YJMCC.2014.01.005
C. M. Clark-Hachtel, D. M. Linz, Y. Tomoyasu, Insights into insect wing origin provided by functional analysis of vestigial in the red flour beetle, Tribolium castaneum Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 16951- 16956 ,(2013) , 10.1073/PNAS.1304332110