A Randomized Controlled Trial of Cognitive Remediation Among Inpatients With Persistent Mental Illness

摘要: Objective: This study evaluated the feasibility and efficacy of a cognitive remediation program in improving work functioning for intermediate- to long-stay psychiatric inpatients. Methods: Eighty-five inpatients with predominantly DSM-IV–defined schizophrenia were randomly assigned or control condition. The consisted 24 hours computerized practice over 12-week period weekly discussion group facilitate transfer skills daily activities. A computer received similar staff exposure without training exercises. comprehensive neuropsychological battery was administered at baseline posttreatment. Symptoms assessed Positive Negative Syndrome Scale (PANSS) baseline, midtreatment (six weeks), posttreatment (12 weeks) six- 12-month follow-ups. Work tracked during follow-up period. Results: average number 45-minute sessions completed 23. Patients demonstrated significantly greater improvements three months than composite measure overall functioning, psychomotor speed, verbal learning. In addition, patients who worked more weeks both groups showed significant comparable on positive, activation, depression subscales PANSS. Conclusions: Cognitive feasible treatment this effective intervention. Longer-term indicated that associated better outcomes, suggesting benefits psychosocial functioning. (Psychiatric Services 59:241–247, 2008)