Evaluation of antiproliferative and anti-inflammatory effects of non-pomace sediment of red grape juices (Vitis labrusca L.) in healthy and cancer cells after in vitro gastrointestinal simulation

摘要: Abstract Grape polyphenols are studied for their bioactive activities and health benefits. juice clarification produces a colored non-pomace solid residue that is rich in may have potential nutraceutical applications. This study therefore firstly investigated antiproliferative anti-inflammatory properties of the sediment Bordo Isabel grape juices before after gastrointestinal simulation, evaluated effects main individual phenolic compounds found these sediments regards to action healthy cancer cells. The inhibited significantly proliferation colorectal adenocarcinoma cells (Caco-2) cells, whereas digested fractions hepatocellular carcinoma (HepG2) However, exposure treatments caused no cell toxicity When tested individually, quercetin myricetin showed activity led viability 56.47 51.07 % Caco-2 33.96 27.03 HepG2 respectively. its exhibited by inhibiting release tumor necrosis factor alpha (TNF-α) murine macrophages. These encouraging data suggests use this as dietary supplement or promising chemotherapy antitumor therapies.