Evolution of myocardial perfusion during primary angioplasty in spontaneously reperfused infarct-related artery: Impact on long-term clinical outcomes and left ventricular function recovery

摘要: Abstract Background TIMI myocardial perfusion grade (TMPG) reflects the integrity of microvasculature in ST-elevation infarction (STEMI). We sought to investigate whether TMPG evolution during primary angioplasty (pPCI) spontaneously reperfused STEMI patients might predict long-term outcomes. Methods 392 with TIMI-3 flow before pPCI were analyzed. According pre- and post-pPCI four reperfusion patterns created: A. deterioration from 2/3 0/1 after ( n =55, 14.0%), B. TMPG-0/1 =111, 28.3%), C. improvement =52, 13.3%), D. TMPG-2/3 =174, 44.4%). 30-day 1-year mortality heart failure requiring hospitalization (HF-hosp) recorded. Left ventricular ejection fraction (LVEF) was measured at first day (1D) 6 months (6M). Results 1D-LVEF similar A–D groups. After 6M, LVEF improved pattern D (7.5±5.4%, p =0.006). Conclusions Maintaining or improving through implies LV function recovery good survival. In contrast, substantial is associated lack recovery, highest rate.