Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering.
作者： Kenta Haraya , Tatsuhiko Tachibana , Tomoyuki Igawa
DOI: 10.1016/J.DMPK.2018.10.003
关键词:
摘要: Monoclonal antibodies (mAbs) have become an important therapeutic option for several diseases. Since mAbs shown promising efficacy in clinic, the competition to develop has severe. In efforts gain a competitive advantage over other and provide significant benefits patients, innovations antibody engineering aimed at improving pharmacokinetic properties of mAbs. Because can therapeutics that are more convenient, safer, efficacious patients disease areas, it is attractive approach patients. Further advances modulate their pharmacokinetics were driven by increase total soluble target antigen concentration often observed after injecting mAb, which then requires high dosage antagonize. To decrease required dosage, techniques been invented reduce antigen. Here, we review various ways improve
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