Mercapto-responsive polymeric nano-carrier capable of releasing sulfur dioxide

摘要: Stimuli-responsive polymeric nano-capsules toward a specific biological signaling molecule show great potential in the fabrication of smart and efficient controlled drug vehicles. Herein, we have designed synthesized an amphiphilic diblock copolymer PEG45-b-PDNPSEMA16 (PEG = poly(ethylene glycol) PDNPSEMA poly(2-(((2,4-dinitrophenyl)sulfonyl)oxy)ethyl methacrylate); subscripts represent mean number repeat units each block) with 2,4-dinitrophenylsulfonyl ester. could self-assemble to form spherical micelles aqueous media. The core formed contains hydrophobic domains, which can load species within core. ester moiety be selectively cleaved upon incubation mercapto-containing give SO2, serve as SO2 carrier. Thus, exhibit ability alter amphiphilicity further self-assembly behavior PEG45-b-PDNPSEMA16. release payloads accelerated specifically by triggering species. We envisage that this polymer model broaden scope responsive macromolecular systems provide new platform fabricate mercapto-responsive biomedicine materials.