The Role of Genotoxic and Nongenotoxic Agents in Multistage Carcinogenesis of Mouse Skin

摘要: The successful completion of each stage in the multistep transformation a normal cell to malignancy involves number intrinsically unlikely events. A limited target genes, either proto-oncogenes or tumour suppressor require be mutated appropriate manner confer selective growth advantage on cell. Such mutational events can take place spontaneously they may induced by exposure chemical physical mutagens. In latter case, must escape direct toxic effects carcinogenic agent and some way circumvent its own attempts enter suicide pathway, which is frequent primary response DNA-damaging agents. All this must, course, within correct cell, i.e., stem with naturally extended lifespan, more committed acquire an lifespan upon stimulus.