Cyclodextrin-Mediated Drug Release from Liposomes Dispersed Within a Bioadhesive Gel
作者： Laïla Boulmedarat , Géraldine Piel , Amélie Bochot , Sylviane Lesieur , Luc Delattre
DOI: 10.1007/S11095-005-4591-2
关键词:
摘要: The aim of the present study was to design a new mucosal drug delivery system composed liposomes dispersed within bioadhesive hydrogel containing methyl-β-cyclodextrin (MeβCD) for controlled release. A hydrophilic model molecule, inulin, encapsulated positively charged and PEG-ylated its release measured in presence MeβCD after vesicle dispersion Carbopol® 974P gel. Freeze-fracture electron microscopy (FFEM) used follow liposome morphological changes when hydrogel. Liposome-MeβCD interactions were investigated by turbidity monitoring during continuous addition FFEM. Inulin diffusion gel influenced concentration since no erosion occurred. When gel, displayed higher stability than vesicles. In MeβCD, amounts free inulin released from liposomes, especially Carbopol®-free system. appeared diffuse towards lipid vesicles permeabilized their bilayer allowing leakage. Indeed, freeze-fracture experiments have shown that behaved as detergent behavior, resulting solubilization. is able mediate, hydrogel, liposome-encapsulated molecule further application this administration.
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Boddé He, Junginger He, Verhoef Jc, de Vries Me, Developments in buccal drug delivery. Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 8, pp. 271- 303 ,(1991)
Henderik W Frijlink, Anko C Eissens, Nanco R Hefting, Klaas Poelstra, Coenraad F Lerk, Dirk KF Meijer, None, The effect of parenterally administered cyclodextrins on cholesterol levels in the rat. Pharmaceutical Research. ,vol. 8, pp. 9- 16 ,(1991) , 10.1023/A:1015861719134
Zezhi Shao, Ramesh Krishnamoorthy, Ashim K. Mitra, Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluations. Pharmaceutical Research. ,vol. 9, pp. 1157- 1163 ,(1992) , 10.1023/A:1015847604654
Yoshiro OHTANI, Tetsumi IRIE, Kaneto UEKAMA, Kazuhiro FUKUNAGA, Josef PITHA, Differential effects of α‐, β‐ and γ‐cyclodextrins on human erythrocytes FEBS Journal. ,vol. 186, pp. 17- 22 ,(1989) , 10.1111/J.1432-1033.1989.TB15171.X
Amélie Bochot, Elias Fattal, Annette Gulik, Guy Couarraze, Patrick Couvreur, Liposomes dispersed within a thermosensitive gel : A new dosage form for ocular delivery of oligonucleotides Pharmaceutical Research. ,vol. 15, pp. 1364- 1369 ,(1998) , 10.1023/A:1011989202488
Mohamadi A. Sarkar, Drug metabolism in the nasal mucosa. Pharmaceutical Research. ,vol. 9, pp. 1- 9 ,(1992) , 10.1023/A:1018911206646
D HARRIS, Bioadhesive polymers in peptide drug delivery. Biomaterials. ,vol. 11, pp. 652- 658 ,(1990) , 10.1016/0142-9612(90)90023-J
Željka Pavelić, Nataša Škalko-Basnet, Ivan Jalšenjak, Liposomes containing drugs for treatment of vaginal infections European Journal of Pharmaceutical Sciences. ,vol. 8, pp. 345- 351 ,(1999) , 10.1016/S0928-0987(99)00033-0
Elisabeth P. C. Kilsdonk, Patricia G. Yancey, Genevieve W. Stoudt, Faan Wen Bangerter, William J. Johnson, Michael C. Phillips, George H. Rothblat, Cellular Cholesterol Efflux Mediated by Cyclodextrins Journal of Biological Chemistry. ,vol. 270, pp. 17250- 17256 ,(1995) , 10.1074/JBC.270.29.17250
Stefan J. Sveinsson, W. Peter Holbrook, Oral mucosal adhesive ointment containing liposomal corticosteroid International Journal of Pharmaceutics. ,vol. 95, pp. 105- 109 ,(1993) , 10.1016/0378-5173(93)90396-W