Painful Neuron-Microglia Interactions in the Trigeminal Sensory System

摘要: The trigeminal sensory system is unique in its innervation of structures specific to the orofacial area. Nocicep- tive afferents are known synapse with second-order neurons subnucleus caudalis (Sp5C) brain stem. activity within Sp5C responsible for relay nociceptive signals higher centers. Recent evidence suggests that central sensitization may be fundamental many trigeminal-specific painful neu- ropathies, including neuralgia and migraine. Glia emerging as prime suspects sensitization. In particular, microglial activation has been implicated development neuropathic pain. It possible activated microglia release factors alter or synaptic peripheral terminals Sp5C. Microglial characterized by changes morphology, expression membrane receptors ion chan- nels, well alterations cytokine chemokine release. addition, have studied slice dissociated culture where P2X receptor potassium channel cur- rents. However, little about resting properties and, furthermore, how these affected following nerve injury. This review summarizes anatomical patho- physiological importance focuses on recent studies system. final part aims link important aspects physiology their potential role chronic pain conditions.