In vitro evaluation of a controlled-release site-specific diisovaleryl tert-butalone chemical delivery system for the eye.

摘要: Cellulosic polymers such as cellulose acetate (CA), butyrate (CAB), and hydroxypropyl methyl phthalate (HPMCP) hydrogels (hydroxyethyl/hydroxypropyl acrylate methacrylate monomers) were used to sustain/control the release of diisovaleryl tert-butalone, a novel site-specific chemical delivery system (CDS) for potential antiglaucoma treatment. Diisovaleryl tert-butalone was incorporated into cellulosic by method "solution casting" "impregnation." In vitro release-rate kinetics from these systems studied using closed sink kinetic model. The rate CDS chosen followed first-order sustained about 2-6 h. case pronounced "burst release" observed. Increasing percentage cross-linker in linear monomers hydrogel shown sustain longer. When one polymers, butyrate, CDS-beta-cyclodextrin [heptakis(2,6-di-O-methyl)-beta-cyclodextrin] inclusion complex, pattern approximated Higuchi's expression monolithic matrix system, where amount released polymer proportional square-root time. Further, stability improved when it dispersed CD complex.